氨磷汀

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Amifostine

產品編號：CL1024 CAS No.：20537-88-6 MDLNo：MFCD00233058 分子式：C5H15N2O3PS 分子量：214.22

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基本信息

英文名稱	Amifostine
中文名稱	氨磷汀
CAS號	20537-88-6
分子式	C5H15N2O3PS
分子量	214.22
MDL	MFCD00233058
外觀	White to off-white powder
儲存條件	Powder -20°C3 years ; 4°C 2 years ;\| In solvent -80°C 6 months ; -20°C 1 month

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產品詳情

Amifostine (WR2721) is a potent cytoprotective and radioprotective agent, selectively safeguarding normal tissues from chemotherapy and radiation-induced damage. It acts as a prodrug, activating to WR-1065 by alkaline phosphatase, which scavenges free radicals and protects cells. Amifostine also induces HIF-α1 and p53, key regulators in the cellular response to hypoxia and DNA damage. Its antiangiogenic properties, by modulating VEGF-A, suggest potential in inhibiting tumor vasculature. Recent studies highlight its renal toxicity reduction and explore PEGylation to enhance safety and efficacy, making Amifostine a versatile protector in cancer therapies.

PMID: 28392886 PMCID: PMC5368387 DOI: 10.1155/2017/4130824

PMID: 17602063 DOI: 10.1634/theoncologist.12-6-738

PMID: 14574457 DOI: 10.1007/s00280-003-0691-z

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