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DMH-1

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DMH-1 (DMH1)

產品編號：CL1057 CAS No.：1206711-16-1 MDLNo： 分子式：C24H20N4O 分子量：380.44
規格 庫存 目錄價 會員專享價 數量
5 mg In-stock ￥400.00 登錄后可見
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10 mg In-stock ￥680.00 登錄后可見
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25 mg In-stock ￥1300.00 登錄后可見
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50 mg In-stock ￥1850.00 登錄后可見
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基本信息
英文名稱 DMH-1 (DMH1)
中文名稱DMH-1
CAS號1206711-16-1
分子式C24H20N4O
分子量380.44
外觀Off-white to yellow powder
產品詳情

Bone morphogenetic proteins (BMP) are secreted signaling proteins, many of which are involved in various developmental processes, in addition to bone formation. DMH1 is an analog of the non-selective BMP receptor inhibitor dorsomorphin. that potently inhibits the kinase activity of activin receptor-like kinase 2 (ALK2; IC50 = 13-108 nM).  It is much less effective at ALK4, ALK5, AMPK, KDR (VEGFR2) or PDGFRβ, although it inhibits ALK1 and ALK3 at nanomolar concentrations.  DMH1 is effective in vivo, as it disrupts dorsoventral development in zebrafish. It also affects stem cell development, increasing cardiomyocyte progenitors and promoting neurogenesis.  DMH1 inhibits the growth of lung cancer cells, reducing tumor growth in a xenograft mouse model. 

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