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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
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規(guī)格

庫存

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會員專享價

數(shù)量

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基本信息

英文名稱	Tagtociclib (PF-07104091)
中文名稱	(1R,3S)-3-(5-(3-(甲氧基甲基)-1-甲基-1H-吡唑-5-甲酰胺基)-1H-吡唑-3-基)環(huán)戊基異丙基氨基甲酸酯
CAS號	2460249-19-6
分子式	C19H28N6O4
分子量	404.46
外觀	Solid powder
儲存條件	Dry, dark and at 0 - 4℃ for short term (days to weeks) or -20℃ for long term (months to years).

產(chǎn)品詳情

Tagtociclib, also known as PF-07104091, is an orally bioavailable inhibitor of cyclin-dependent kinase 2 (CDK2), with potential antineoplastic activity. Upon administration, CDK2 inhibitor PF-07104091 selectively targets, binds to and inhibits the activity of CDK2. This may lead to cell cycle arrest, the induction of apoptosis, and the inhibition of tumor cell proliferation. CDKs are serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation and are frequently overexpressed in tumor cells. CDK2/cyclin E complex plays an important role in retinoblastoma (Rb) protein phosphorylation and the G1-S phase cell cycle transition. CDK2/cyclin A complex plays an important role in DNA synthesis in S phase and the activation of CDK1/cyclin B for the G2-M phase cell cycle transition.

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(1R,3S)-3-(5-(3-(甲氧基甲基)-1-甲基-1H-吡唑-5-甲酰胺基)-1H-吡唑-3-基)環(huán)戊基異丙基氨基甲酸酯

2460249-19-6 98+%

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(1R,3S)-3-(5-(3-(甲氧基甲基)-1-甲基-1H-吡唑-5-甲酰胺基)-1H-吡唑-3-基)環(huán)戊基異丙基氨基甲酸酯

Tagtociclib (PF-07104091)

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