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規(guī)格	庫存	目錄價(jià)	會員專享價(jià)	數(shù)量
250 mg	In-stock	￥150.00	登錄后可見	- +
500 mg	In-stock	￥200.00	登錄后可見	- +
1 g	In-stock	￥300.00	登錄后可見	- +

基本信息

英文名稱	Gliquidone (Synonyms: AR-DF 26)
中文名稱	格列喹酮
CAS號	33342-05-1
分子式	C27H33N3O6S
分子量	527.63
外觀	White crystalline powder, odorless

安全信息

產(chǎn)品詳情

Gliquidone (Glurenorm,AR-DF 26) is an ATP-sensitive K⁺ channel antagonist with IC50 of 27.2 nM.

Gliquidone is a second generation sulfonylurea that selectively inhibits ATP-sensitive potassium channel currents (IKATP) in pancreatic β-cells (IC50s = 0.45, 119.1, and 149.7 μM for HIT-T15 cells, cardiomyocytes, and vascular smooth muscle cells, respectively). It is also a peroxisome proliferator-activated receptor γ (PPARγ) agonist (EC50 = 10 μM in a transactivation assay). Gliquidone (0.2 nmol/g) decreases plasma levels of D-glucose and stimulates insulin release in anesthetized rats. It decreases blood glucose levels, serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) activities, and hepatic lipid peroxidation and increases hepatic glutathione (GSH) levels in a rat model of diabetes induced by streptozotocin (STZ; Item No. 13104) when administered at a dose of 10 mg/kg.

Gliquidone (AR-DF 26) is an anti-diabetic agent in the sulfonylurea class, used in the treatment of diabetes mellitus type 2.

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CL1154

格列喹酮

33342-05-1 98+% In-stock

￥150.00 250 mg

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格列喹酮

Gliquidone (Synonyms: AR-DF 26)

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