英文名稱 | Alectinib | CH5424802 | RO5424802 | RG7853 |
---|---|
中文名稱 | 艾樂替尼 |
CAS號 | 1256580-46-7 |
分子式 | C30H34N4O2 |
分子量 | 482.62 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | Alectinib | CH5424802 | RO5424802 | RG7853 |
---|---|
中文名稱 | 艾樂替尼 |
CAS號 | 1256580-46-7 |
分子式 | C30H34N4O2 |
分子量 | 482.62 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Alectinib is a potent ALK inhibitor with IC50 of 1.9 nM in cell-free assays, sensitive to L1196M mutation and higher selectivity for ALK than PF-02341066, NVP-TAE684 and PHA-E429.
CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant.
PMID: 21575866 DOI: 10.1016/j.ccr.2011.04.004
PMID: 30215676 PMCID: PMC6290889 DOI: 10.1093/annonc/mdy405