英文名稱 | Ixabepilone | BMS-247550 | Aza-epothilone B |
---|---|
中文名稱 | 伊沙匹隆 |
CAS號 | 219989-84-1 |
分子式 | C27H42N2O5S |
分子量 | 506.70 |
外觀 | White to off-white powder |
儲存條件 | 4°C, protect from light |
英文名稱 | Ixabepilone | BMS-247550 | Aza-epothilone B |
---|---|
中文名稱 | 伊沙匹隆 |
CAS號 | 219989-84-1 |
分子式 | C27H42N2O5S |
分子量 | 506.70 |
外觀 | White to off-white powder |
儲存條件 | 4°C, protect from light |
Ixabepilone is an orally bioavailable microtubule inhibitor. It binds to tubulin and promotes tubulin polymerization and microtubule stabilization, thereby arresting cells in the G2-M phase of the cell cycle and inducing tumor cell apoptosis.
Hunt Discovery of Ixabepilone.
https://doi.org/10.1158/1535-7163.MCT-08-0999