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規格	庫存	目錄價	會員專享價	數量
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規格

庫存

目錄價

會員專享價

數量

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基本信息

英文名稱	SB408124
中文名稱	SB 408124
CAS號	288150-92-5
分子式	C19H18F2N4O
分子量	356.37
外觀	White to off-white powder

安全信息

產品詳情

SB-408124 is a elective non-peptide orexin OX1 receptor antagonist (Kb values are 21.7 and 1405 nM for human OX1 and OX2 receptors respectively). A critical role for the orexin-1 receptor (OX1R) in complex emotional behavior is emerging, such as overactivation of the OX1R pathway being associated with panic or anxiety states.

相關文獻

A major role for perifornical orexin neurons in the control of glucose metabolism in rats.

PMID: 19592616 PMCID: PMC2731521 DOI: 10.2337/db09-0385

Characterisation of the binding of [3H]-SB-674042, a novel nonpeptide antagonist, to the human orexin-1 receptor.

PMID: 14691055 PMCID: PMC1574197 DOI: 10.1038/sj.bjp.0705610

The osmotically and histamine-induced enhancement of the plasma vasopressin level is diminished by intracerebroventricularly administered orexin in rats.

PMID: 22350729 DOI: 10.1007/s00424-012-1080-4

Activation of orexin/hypocretin type 1 receptors stimulates cAMP synthesis in primary cultures of rat astrocytes.

PMID: 21857082 DOI: 10.1016/s1734-1140(11)70583-7