菲卓替尼

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Fedratinib | TG-101348 | SAR 302503

產品編號：CL1888 CAS No.：936091-26-8 MDLNo： 分子式：C27H36N6O3S 分子量：524.68

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基本信息

英文名稱	Fedratinib \| TG-101348 \| SAR 302503
中文名稱	菲卓替尼
CAS號	936091-26-8
分子式	C27H36N6O3S
分子量	524.68
外觀	White to light yellow powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

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產品詳情

Fedratinib, also known as TG101348 and SAR302503, is a JAK2 inhibitor, is also an orally bioavailable, small-molecule, ATP-competitive inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor TG101348 competes with JAK2 as well as the mutated form AK2V617F for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and the induction of tumor cell apoptosis. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders (MPDs); the mutated form JAK2V617F has a valine-to-phenylalanine modification at position 617 and plays a key role in tumor cell proliferation and survival.

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