帕比司他

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Panobinostat

產品編號：CL2002 CAS No.：404950-80-7 MDLNo： 分子式：C21H23N3O2 分子量：349.43

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規格	庫存	目錄價	會員專享價	數量
10 mg	In-stock	￥200.00	登錄后可見	- +
20 mg	In-stock	￥300.00	登錄后可見	- +
100 mg	In-stock	￥1000.00	登錄后可見	- +

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基本信息
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基本信息

英文名稱	Panobinostat
中文名稱	帕比司他
CAS號	404950-80-7
分子式	C21H23N3O2
分子量	349.43
外觀	Light brown powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

安全信息

產品詳情

Panobinostat, also known as NVP LBH-589 or LBH-589, is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2/M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis-related genes, such as hypoxia-inducible factor-1alpha (HIF-1a) and vascular endothelial growth factor (VEGF), thus impairing endothelial cell chemotaxis and invasion. On 2/23/2015, it received FDA accelerated approval for use in patients with multiple myeloma who had received at least 2 previous treatments, including bortezomib and an immunomodulatory agent.

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CL2002

帕比司他

404950-80-7 98+% In-stock

￥200.00 10 mg