英文名稱 | Bosutinib(SKI-606) |
---|---|
中文名稱 | 伯舒替尼 |
CAS號(hào) | 380843-75-4 |
分子式 | C26H29Cl2N5O3 |
分子量 | 530.45 |
外觀 | White to light yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
規(guī)格 | 庫存 | 目錄價(jià) | 會(huì)員專享價(jià) | 數(shù)量 | |
---|---|---|---|---|---|
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英文名稱 | Bosutinib(SKI-606) |
---|---|
中文名稱 | 伯舒替尼 |
CAS號(hào) | 380843-75-4 |
分子式 | C26H29Cl2N5O3 |
分子量 | 530.45 |
外觀 | White to light yellow powder |
儲(chǔ)存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
Bosutinib is a novel, dual Src/Abl inhibitor with IC50 of 1.2 nM and 1 nM in cell-free assays, respectively. Bosutinib also effectively decreases the activity of PI3K/AKT/mTOR, MAPK/ERK and JAK/STAT3 signaling pathways by blocking the phosphorylation levels of p-ERK, p-S6, and p-STAT3. Bosutinib promotes autophagy