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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
500 mg	In-stock	￥286.00	登錄后可見	- +
1 g	In-stock	￥436.00	登錄后可見	- +
5 g	In-stock	￥636.00	登錄后可見	- +

基本信息

英文名稱	Temozolomide \| NSC 362856 \| CCRG 81045 \| TMZ
中文名稱	替莫唑胺
CAS號	85622-93-1
分子式	C6H6N6O2
分子量	194.15
外觀	Off-white crystalline powder
儲存條件	-20°C, protect from light, stored under nitroge

產(chǎn)品詳情

TMZ(Temozolomide) is a monofunctional SN-1 alkylating agent that can modify nitrogen atoms in the DNA ring and the extracyclic oxygen group, chemically converted to MTIC and degrades to methyldiazonium cation, which transfers methyl groups to DNA at physiologic pH. A DNA damage inducer in L-1210 and L-1210/BCNU cells. Temozolomide induces apoptosis and exhibits antitumor activity.

相關文獻

Combined treatment with temozolomide and poly(ADP-ribose) polymerase inhibitor enhances survival of mice bearing hematologic malignancy at the central nervous system site.

PMID: 11877304 DOI: 10.1182/blood.v99.6.2241

Temozolomide Resistance in Glioblastoma Cell Lines: Implication of MGMT, MMR, P-Glycoprotein and CD133 Expression.

PMID: 26447477 PMCID: PMC4598115 DOI: 10.1371/journal.pone.0140131

Combining Anti-Human VEGF with temozolomide increases the antitumor efficacy of temozolomide in a human glioblastoma orthotopic xenograft model.

Neoplasia. 2008 Dec;10(12):1383-92.

Temozolomide induces senescence but not apoptosis in human melanoma cells.

PMID: 17968428 PMCID: PMC2360470 DOI: 10.1038/sj.bjc.6604017