英文名稱 | XAV-939 |
---|---|
中文名稱 | 2-(4-(三氟甲基)苯基)-3,5,7,8-四氫-4H-硫代吡喃并[4,3-d]嘧啶-4-酮 |
CAS號 | 284028-89-3 |
分子式 | C14H11F3N2OS |
分子量 | 312.31 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
英文名稱 | XAV-939 |
---|---|
中文名稱 | 2-(4-(三氟甲基)苯基)-3,5,7,8-四氫-4H-硫代吡喃并[4,3-d]嘧啶-4-酮 |
CAS號 | 284028-89-3 |
分子式 | C14H11F3N2OS |
分子量 | 312.31 |
外觀 | White to off-white powder |
儲存條件 | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
XAV-939 (NVP-XAV939) selectively inhibits Wnt/β-catenin-mediated transcription through tankyrase1/2 inhibition with IC50 of 11 nM/4 nM in cell-free assays, regulates axin levels and does not affect CRE, NF-κB or TGF-β.