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首頁(yè) > 產(chǎn)品目錄 > 信號(hào)通路 > Microbiology/Virology/ Anti-infection > HIV Protease > 地瑞那韋/達(dá)蘆那韋

地瑞那韋/達(dá)蘆那韋

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Darunavir (TMC114)

產(chǎn)品編號(hào)：CL2205 CAS No.：206361-99-1 MDLNo： 分子式：C??H??N?O?S 分子量：547.66
規(guī)格 庫(kù)存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
200 mg In-stock ￥300.00 登錄后可見(jiàn)
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500 mg In-stock ￥450.00 登錄后可見(jiàn)
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1 g In-stock ￥750.00 登錄后可見(jiàn)
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5 g In-stock ￥3000.00 登錄后可見(jiàn)
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基本信息
英文名稱 Darunavir (TMC114)
中文名稱地瑞那韋/達(dá)蘆那韋
CAS號(hào)206361-99-1
分子式C??H??N?O?S
分子量547.66
外觀White to off-white powder
儲(chǔ)存條件 Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

Darunavir is a drug used to treat HIV infection. It is in the protease inhibitor class. Darunavir is an orally-bioavailable non-peptidic inhibitor of human immunodeficiency virus type 1 (HIV-1) protease that selectively inhibits HIV-1 protease enzyme induced cleavage of gag and gag-pol poly-proteins preventing the maturation of virions and also inhibits the dimerization of HIV-1 protease suppressing proteolytic activity and subsequent replication of HIV-1. Study results have shown that darunavir exhibits potent inhibition against HIV-1 with a value of 50% inhibition concentration IC50 of 0.003 μmol/L in HIV-1 infected MT-2 cells. Darunavir binds to HIV-1 protease with considerably high affinity and fits closely with the substrate envelop leading to its potent ability to inhibit multidrug-resistant HIV strains. Prezista is an OARAC recommended treatment option for treatment-na?ve and treatment-experienced adults and adolescents. 


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