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ABT-737

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ABT-737

產(chǎn)品編號(hào):CL2344 CAS No.:852808-04-9 MDLNo: 分子式:C42H45ClN6O5S2 分子量:813.43
規(guī)格 庫(kù)存 目錄價(jià) 會(huì)員專享價(jià) 數(shù)量
5 mg In-stock ¥480.00 登錄后可見(jiàn)
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10 mg In-stock ¥760.00 登錄后可見(jiàn)
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基本信息
英文名稱 ABT-737
中文名稱ABT-737
CAS號(hào)852808-04-9
分子式C42H45ClN6O5S2
分子量813.43
外觀Yellow to orange powder
儲(chǔ)存條件Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).
產(chǎn)品詳情

ABT-737 is an orally available inhibitor of the nuclear enzymes poly(ADP-ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, ABT-767 selectively binds to PARP 1 and 2, thereby preventing repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of DNA strand breaks and promotes genomic instability eventually leading to apoptosis. ABT-767 may enhance the cytotoxicity of DNA-damaging agents and reverse tumor cell chemo- and radioresistance.


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