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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
5 mg	3-5days	￥578.00	登錄后可見	- +
10 mg	3-5days	￥1088.00	登錄后可見	- +

基本信息

英文名稱	Telaglenastat \| CB-839
中文名稱	CB-839
CAS號	1439399-58-2
分子式	C26H24F3N7O3S
分子量	571.57
外觀	Off-white to yellow powder
儲存條件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

產(chǎn)品詳情

Telaglenastat (CB-839) is a first-in-class, selective, reversible and orally active glutaminase 1 (GLS1) inhibitor. Telaglenastat selectively inhibits GLS1 splice variants KGA (kidney-type glutaminase) and GAC (glutaminase C) compared to GLS2. The IC₅₀s are 23 nM and 28 nM for endogenous glutaminase in mouse kidney and brain, respectively. Telaglenastat inuduces autophagy and has antitumor activity.

PMID: 34731180 PMCID: PMC8565744 DOI: 10.1371/journal.pone.0259241

PMID: 24523301 DOI: 10.1158/1535-7163.MCT-13-0870

PMID: 28671190 PMCID: PMC5500878 DOI: 10.1038/ncomms15965

PMID: 31429768 PMCID: PMC6700828 DOI: 10.1186/s12964-019-0412-9

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瀏覽記錄

CL2411

CB-839

1439399-58-2 98+% 3-5days

￥578.00 5 mg

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CB-839

Telaglenastat | CB-839

化學品安全說明書(MSDS)