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規(guī)格	庫(kù)存	目錄價(jià)	會(huì)員專(zhuān)享價(jià)	數(shù)量
1 mg	3-5days	￥500.00	登錄后可見(jiàn)	- +
5 mg	3-5days	￥1500.00	登錄后可見(jiàn)	- +
10 mg	3-5days	￥2600.00	登錄后可見(jiàn)	- +

規(guī)格

庫(kù)存

目錄價(jià)

會(huì)員專(zhuān)享價(jià)

數(shù)量

1 mg

3-5days

￥500.00

登錄后可見(jiàn)

- +

5 mg

3-5days

￥1500.00

登錄后可見(jiàn)

- +

10 mg

3-5days

￥2600.00

登錄后可見(jiàn)

- +

基本信息

英文名稱(chēng)	OTS514 hydrochloride
中文名稱(chēng)	OTS514 hydrochloride
CAS號(hào)	2319647-76-0
分子式	C21H21ClN2O2S
分子量	400.92
外觀(guān)	Light yellow to yellow powder
儲(chǔ)存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

安全信息

產(chǎn)品詳情

OTS514 HCl (OTS 514; OTS-514), the hydrochloride salt of OTS514, is a novel and highly potent inhibitor of the TOPK (T-LAK cell-originated protein kinase) with potential antineoplastic activity. Its IC50 value of 2.6 nM indicates that it inhibits TOPK. The growth of TOPK-positive cancer cells was significantly suppressed by it. Moreover, it demonstrates a strong growth-inhibitory effect on ovarian cancer cell lines, with IC50 values ranging from 3.0 to 46 nM. OTS514 can cause apoptotic cell death in small cell lung cancer by exhibiting growth inhibitory effects, with an IC50 range of 0.4 ~ 42.6 nM. The activity of a protein involved in the stemness of CSC, forkhead box protein M1 (FOXM1), was also suppressed by OTS514. Additionally, OTS514 treatment exhibited increased cytotoxicity against lung sphere-derived CSC-like SCLC cells and decreased CD90-positive SCLC cells.

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CL2491A

OTS514 hydrochloride

2319647-76-0 98+% 3-5days

￥500.00 1 mg

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OTS514 hydrochloride

OTS514 hydrochloride

化學(xué)品安全說(shuō)明書(shū)(MSDS)