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規(guī)格	庫存	目錄價	會員專享價	數(shù)量
5 mg	3-5days	￥620.00	登錄后可見	- +
10 mg	3-5days	￥1000.00	登錄后可見	- +
25 mg	3-5days	￥1800.00	登錄后可見	- +

規(guī)格

庫存

目錄價

會員專享價

數(shù)量

5 mg

3-5days

￥620.00

登錄后可見

- +

10 mg

3-5days

￥1000.00

登錄后可見

- +

25 mg

3-5days

￥1800.00

登錄后可見

- +

基本信息

英文名稱	Rebastinib (DCC-2036)
中文名稱	Rebastinib (DCC-2036)
CAS號	1020172-07-9
分子式	C30H28FN7O3
分子量	553.59
外觀	White to off-white powder
儲存條件	Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years).

產(chǎn)品詳情

Rebastinib (formerly also known as DCC-2036), a novel, potent and orally bioavailable small-molecule inhibitor of multiple tyrosine kinases with potential antineoplastic activity, is a conformational control Bcr-Abl inhibitor for Abl1(WT) and Abl1(T315I) with IC50s of 0.8 nM and 4 nM. It also inhibits other kinases such as SRC, LYN, FGR, HCK, KDR, FLT3, and Tie-2, and has low activity towards c-Kit. DCC-2036 inhibits ABL1 through forcing the kinase domains into inhibitor-bound, inactive Type II conformations. In cellular assay, DCC-2036 inhibits the proliferation of Ba/F3 and K562 cells with IC50 values of 5.4nM and 5.5nM, respectively.

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CL2536

Rebastinib (DCC-2036)

1020172-07-9 98+% 3-5days

￥620.00 5 mg

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Rebastinib (DCC-2036)

Rebastinib (DCC-2036)

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