英文名稱 | PF-477736 | PF-736 | PF-00477736 |
---|---|
中文名稱 | PF-477736 | PF-736 | PF-00477736 |
CAS號(hào) | 952021-60-2 |
分子式 | C22H25N7O2 |
分子量 | 419.48 |
英文名稱 | PF-477736 | PF-736 | PF-00477736 |
---|---|
中文名稱 | PF-477736 | PF-736 | PF-00477736 |
CAS號(hào) | 952021-60-2 |
分子式 | C22H25N7O2 |
分子量 | 419.48 |
PF-477736 (PF-736, PF-00477736) is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM in a cell-free assay and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes. It shows ~100-fold selectivity for Chk1 than Chk2.
PMID: 18723486 DOI: 10.1158/1535-7163.MCT-07-2391
PMID: 20675383 PMCID: PMC2963387 DOI: 10.1074/jbc.M110.122705