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規格	庫存	目錄價	會員專享價	數量
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規格

庫存

目錄價

會員專享價

數量

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基本信息

英文名稱	R547 \| Ro 4584820
中文名稱	R547 \| Ro 4584820
CAS號	741713-40-6
分子式	C18H21F2N5O4S
分子量	441.45
外觀	White to off-white powder
儲存條件	Store in a dry and dark sealed container, short-term (weeks to months) storage at 0-4 ℃, long-term (months to years) storage at -20 ℃.

安全信息

產品詳情

R547 (Ro 4584820) is a potent ATP-competitive inhibitor of CDK1/2/4 with K_i of 2 nM/3 nM/1 nM. It is less potent to CDK7 and GSK3α/β, while inactive to other kinases.

相關文獻

In vitro and in vivo activity of R547: a potent and selective cyclin-dependent kinase inhibitor currently in phase I clinical trials.

PMID: 17121911 DOI: 10.1158/1535-7163.MCT-06-0355

Discovery of [4-Amino-2-(1-methanesulfonylpiperidin-4-ylamino)pyrimidin-5-yl](2,3-difluoro-6- methoxyphenyl)methanone (R547), a potent and selective cyclin-dependent kinase inhibitor with significant in vivo antitumor activity.

PMID: 17064073 DOI: 10.1021/jm0606138

Assessment of network perturbation amplitudes by applying high-throughput data to causal biological networks.

PMID: 22651900 PMCID: PMC3433335 DOI: 10.1186/1752-0509-6-54

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