英文名稱 | RapaLink-1 |
---|---|
中文名稱 | RapaLink-1 |
CAS號(hào) | 1887095-82-0 |
分子式 | C91H138N12O24 |
分子量 | 1,784.14 |
外觀 | White to light yellow powder |
儲(chǔ)存條件 | -20°C, sealed storage, away from moisture |
英文名稱 | RapaLink-1 |
---|---|
中文名稱 | RapaLink-1 |
CAS號(hào) | 1887095-82-0 |
分子式 | C91H138N12O24 |
分子量 | 1,784.14 |
外觀 | White to light yellow powder |
儲(chǔ)存條件 | -20°C, sealed storage, away from moisture |
Rapalink-1 is a brain-permeable mTOR inhibitor that inhibits oxidative stress-induced DNA damage and senescence in ethanol-exposed endothelial cells, and inhibits the mTORC1-4E-BP1 pathway in mice.Rapalink-1 is used for the study of prostate cancer due to its anticancer activity.
A Kinase Inhibitor Targeted to mTORC1 Drives Regression in Glioblastoma.
PMID: 28292440 PMCID: PMC5386178 DOI: 10.1016/j.ccell.2017.01.014
Overcoming mTOR resistance mutations with a new-generation mTOR inhibitor.
PMID: 27279227 PMCID: PMC4902179 DOI: 10.1038/nature17963
PMID: 32232883 PMCID: PMC7226215 DOI: 10.1111/cas.14395