英文名稱 | Sivelestat | EI546 | LY544349 | ONO5046 |
---|---|
中文名稱 | 西維來司他 |
CAS號 | 127373-66-4 |
分子式 | C20H22N2O7S |
分子量 | 434.46 |
外觀 | White to off-white powder |
儲存條件 | 4°C, protect from light |
英文名稱 | Sivelestat | EI546 | LY544349 | ONO5046 |
---|---|
中文名稱 | 西維來司他 |
CAS號 | 127373-66-4 |
分子式 | C20H22N2O7S |
分子量 | 434.46 |
外觀 | White to off-white powder |
儲存條件 | 4°C, protect from light |
Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19.
PMID: 17203197
PMID: 18165924 DOI: 10.1007/s11010-007-9698-9